AHARA Science | 1,469 Metabolites | Independent Lab Validation

Our Science

 

Metabolomic Research

1,469 metabolites. Independently validated.

The most comprehensive metabolomic characterization of medicinal mushroom extracts ever conducted. Dual-panel mass spectrometry. Published in full.

Validated by Independent Metabolomic Laboratory — Japan
1,469
Metabolites
Identified
8,757
Molecular
Features
75
Absolutely
Quantified
17
Therapeutic
Pathways
Methodology

How we measured it

February 2026. An independent metabolomic laboratory in Japan conducted a dual-panel analysis of AHARA's extracts.

CE-MS
Capillary Electrophoresis
Ionic and polar metabolites
LC-MS
Liquid Chromatography
Lipids and hydrophobic compounds
nmol/g
Absolute Quantification
75 compounds with exact concentrations
Quantified Compounds

What's inside — verified

75 compounds absolutely quantified. Exact concentrations, not estimates. Exact concentrations, not estimates.

Compound Amount Function
Succinic acid 26.58 mg / serving SUCNR1 anti-inflammatory receptor activation
Lactic acid 16.32 mg Metabolic signaling, pH regulation
Citric acid 8.53 mg Krebs cycle — cellular energy
Choline 5.74 mg Acetylcholine precursor — memory
GABA Quantified Primary calming neurotransmitter
Adenine Quantified Direct adenosine precursor — sleep
Hypoxanthine 170× enriched Second adenosine pathway
Oleamide Detected Endogenous sleep molecule
Cytidine 173× enriched Cholinergic precursor — cognition
GPC 78× enriched Crosses blood-brain barrier
Ergosterol 44× enriched Vitamin D2 precursor
Sphingolipids 23× enriched Myelin sheath — nerve insulation
Therapeutic Coverage

17 pathways mapped

Not a single-mechanism supplement.

GABAergic

Calming + sleep

Cholinergic

Memory + attention

Purine / Adenosine

Natural sleep pressure

Serotonergic

Mood regulation

Endocannabinoid

Sleep + pain

Neuroprotective

Neuron repair

Gut-Brain Axis

Microbiome signaling

Anti-Inflammatory

26 ganoderic acids

Immunomodulatory

Beta-glucan regulation

Neurogenesis

NGF neuron growth

Myelination

Nerve insulation

Hepatoprotective

Liver support

Cardiovascular

Circulation

Metabolic

Krebs cycle

Antioxidant

Ergothioneine

Membrane

Phospholipid precursors

Stress Response

HPA axis

Our Research

Three breakthroughs

Extraction

Water-based. No solvents.

Proprietary process that recovered all 26 ganoderic acids without ethanol or methanol — verified by mass spectrometry. Full polysaccharide preservation. Full triterpene recovery.

Clinical

85% improvement. p<0.001.

30-day observational study using PSQI — the gold-standard validated sleep instrument. Sleep onset dropped from 65 to 22 minutes. Zero tolerance. Zero grogginess. 150-person RCT underway in 2026.

Delivery

Sublingual nanofiber.

Bypasses first-pass liver metabolism. Validated by University of Maryland TEM imaging. Co-developed with Dr. Subhas Malghan, Ph.D. (UC Berkeley) — co-author of the FDA's first nanotechnology guidance document.

Independent Verification

Every claim. Third-party validated.

Metabolomics

Independent metabolomic laboratory, Japan
CE-MS + LC-MS dual-panel

Nanofiber Structure

University of Maryland
Transmission Electron Microscopy

Compound Purity

ANAB-accredited laboratories
HPLC + mass spectrometry

  1. AHARA (2026). Comprehensive Metabolomic Characterization. Validated by Independent metabolomic laboratory, Japan.
  2. AHARA (2026). 30-Day Observational Sleep Study. PSQI-validated. p<0.001.
  3. University of Maryland (2025). TEM Imaging — Nanofiber Structure Validation

1,469 metabolites. 17 pathways. Every claim independently verified.

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