Reishi mushrooms (Ganoderma lucidum) have been the subject of several scientific studies investigating their potential to improve sleep quality. Research suggests that reishi may offer benefits for sleep through various mechanisms.
Effects on Sleep Parameters
A study published in the journal Nature and Science of Sleep examined the effects of Ganoderma lucidum spore extract on sleep disturbances in a rat model of Alzheimer's disease. The researchers found that treatment with the extract for 14 days significantly improved total sleep time, rapid eye movement (REM) sleep time, and non-REM sleep time in the rats2. This suggests that reishi may have potential in addressing sleep issues associated with neurodegenerative conditions.
Mechanism of Action
The sleep-promoting effects of reishi appear to involve multiple pathways:
- Neurotransmitter Modulation: A study in the International Journal of Medicinal Mushrooms reported that Ganoderma lucidum extract increased levels of 5-hydroxytryptamine (serotonin) in the hypothalamus, a neurotransmitter involved in sleep regulation
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Anti-inflammatory Effects: Research published in Frontiers in Pharmacology demonstrated that reishi extract inhibited the NF-κB/NLRP3 inflammatory pathway in the medial prefrontal cortex, which may contribute to its sleep-promoting effects
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GABA-ergic Activity: The same study found that reishi ameliorated the lower activity of γ-aminobutyric acid (GABA)-ergic neurons in the parabrachial nucleus, a region involved in sleep regulation
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Gut Microbiota Interaction
Interestingly, a study in Scientific Reports suggested that reishi may promote sleep through a gut microbiota-dependent mechanism. The researchers found that administration of reishi extract altered the gut microbiome composition and increased levels of sleep-promoting metabolites3.
Clinical Relevance
While most studies have been conducted in animal models, some clinical research has shown promising results. A randomized clinical trial reported in the International Journal of Medicinal Mushrooms found that patients taking Ganoderma lucidum experienced an increased sense of well-being and reductions in fatigue.
It's important to note that while these findings are promising, more extensive clinical trials are needed to fully validate the long-term safety and efficacy of reishi for sleep improvement in humans. As with any supplement, it's advisable to consult with a healthcare professional before incorporating reishi into your wellness routine, especially if you have existing health conditions or are taking medications.
References
Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials
